{"id":157545,"date":"2023-06-01T16:48:00","date_gmt":"2023-06-01T16:48:00","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=157545"},"modified":"2024-12-10T17:30:28","modified_gmt":"2024-12-10T23:30:28","slug":"ronald-depinho","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/health\/ronald-depinho\/","title":{"rendered":"\u201cThe next years are going to be the golden era of cancer therapy\u201d"},"content":{"rendered":"\n<p>Ronald DePinho&#8217;s life mission is to fight cancer through scientific research. At the panel <a href=\"https:\/\/tecscience.tec.mx\/en\/tag\/giants-of-medicine\/\" target=\"_blank\" rel=\"noreferrer noopener\">Giants of Medicine<\/a>, held on May 16, 2023, and organized by <a href=\"https:\/\/tecscience.tec.mx\/en\/tag\/tecsalud\/\" target=\"_blank\" rel=\"noreferrer noopener\">TecSalud<\/a>, DePinho spoke about his greatest achievements with <a href=\"https:\/\/tecscience.tec.mx\/en\/health\/guillermo-torre-tecscience\/\" target=\"_blank\" rel=\"noreferrer noopener\"><strong>Guillermo Torre<\/strong><\/a>, TecSalud Dean and Vice President for Research at Tecnol\u00f3gico de Monterrey.<\/p>\n\n\n\n<p>DePinho is a research physician and former University of Texas MD Anderson Cancer Center president. Even though his parents were <strong>low-income Portuguese immigrants living in New York<\/strong>, with their support he achieved levels of success he never imagined. \u201cEvery chapter was one that I did not anticipate,\u201d he said.<\/p>\n\n\n\n<p>For his tireless work in cancer, he has received multiple awards and distinctions such as the American Association for Cancer Research (AACR) Clowes Memorial Award, the Ellis Island Medal of Honor, and Commander of the Order of Santiago of the Sword, Portugal.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Gigantes de la Medicina - Dr. Ronald A. DePinho\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/8pjXHVnYP2E?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Ronald DePinho, a giant is born<\/strong><\/h2>\n\n\n\n<p>His passion for science began when in high school he dissected a frog and became fascinated. He wanted to understand the complexity of a living body. \u201cI was instantly addicted to biology,\u201d he said.<\/p>\n\n\n\n<p>Although his first love was research, he also wanted to be in contact with people and have that \u201cvery special bond that physicians or healthcare providers have with their patients,\u201d he recalled.<\/p>\n\n\n\n<p>With this in mind, he studied biology at Fordham University, New York, from where he graduated with honors. He then earned a Master&#8217;s degree in microbiology and immunology from the<a href=\"https:\/\/www.einsteinmed.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\"> Albert Einstein College of Medicine<\/a>.<\/p>\n\n\n\n<p>After graduating, he took a break to become a physician and complete his internal medicine internship and residency at the Columbia- Presbyterian Medical Center. Taking care of patients, he realized that what interested him most was understanding what causes diseases, not just how to treat them.<\/p>\n\n\n\n<p>Then, he decided to continue with a postdoc at the Albert Einstein School of Medicine. There arose the question that would guide the rest of his career: <strong>why does aging cause cancer?<\/strong><\/p>\n\n\n\n<p>&#8220;We were very interested in trying to understand and answer this basic question because it&#8217;s the most important driver for cancer,&#8221; he said.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Cancer and aging<\/strong><\/h2>\n\n\n\n<p>In the Department of Microbiology and Immunology at the Albert Einstein College of Medicine, DePinho focused on studying telomeres and their relationship to cancer and aging.<\/p>\n\n\n\n<p><strong>Telomeres are the ends of chromosomes<\/strong>, which in turn are the structures in which our DNA is organized within cells. Their function is to give stability to chromosomes and it has been observed that as the species get older they become shorter, which causes damage to the cells and leads to their death.<\/p>\n\n\n\n<p>In collaboration with <a href=\"https:\/\/www.nobelprize.org\/womenwhochangedscience\/stories\/carol-greider\" target=\"_blank\" rel=\"noreferrer noopener\">Carol Greider<\/a>, who won the 2009 Nobel Prize in Medicine, and two other researchers, he <a href=\"https:\/\/www.cell.com\/cell\/fulltext\/S0092-8674(01)80006-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867401800064%3Fshowall%3Dtrue#%20\" target=\"_blank\" rel=\"noreferrer noopener\">created the first telomerase knockout mouse<\/a>. <strong>Knockout mice are genetically modified so a specific gene or section of DNA can be removed in order to see what happens if the gene or sector isn&#8217;t there<\/strong>.<\/p>\n\n\n\n<p>These mice allowed DePinho and his colleagues to deepen their understanding of the relationship of telomere dysfunction to cancer and aging. What was learned was also useful to understand other degenerative diseases, such as fibrosis.<\/p>\n\n\n\n<p>As his interest in cancer grew, he made the decision to move to Boston to found his laboratory at Harvard University. There, his main goal was to improve the precision of cancer drug development. \u201cUsing science to identify [genetic] targets [of cancer] and drugs against those targets,\u201d he said.<\/p>\n\n\n\n<p>In Boston, he founded the <a href=\"https:\/\/mdanderson.elsevierpure.com\/en\/organisations\/institute-for-applied-cancer-science-iacs\" target=\"_blank\" rel=\"noreferrer noopener\">Belfer Institute for Applied Cancer Sciences<\/a> where he spent 14 years before becoming president of the University of Texas MD Anderson Cancer Center. Back in Texas, one of his greatest achievements was founding the <a href=\"https:\/\/www.mdanderson.org\/about-md-anderson\/facts-history\/moon-shots-program.html\" target=\"_blank\" rel=\"noreferrer noopener\">Moon Shots Program<\/a>, which focused on accelerating the application of the knowledge acquired in effective treatments to cure many types of cancer.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>The future in the fight against cancer<\/strong><\/h2>\n\n\n\n<p>According to DePinho, the future of the fight against cancer will be focused on seeking therapies that target regulatory mechanisms beyond T cells, a type of white blood cell that is affected in the development of the disease and cannot destroy cancer cells.<\/p>\n\n\n\n<p>\u201cThe next 10 to 20 years are going to be the golden era of cancer therapy,\u201d he said. &#8220;This is an exciting time because we now have the technology to be able to make a decisive assault on cancer.&#8221;<\/p>\n\n\n\n<p>In addition, he emphasized that, in order to really defeat it, it is essential to focus many efforts on prevention and early detection of cancer, since up to 50% of types can be prevented.<\/p>\n\n\n\n<p>To medical students looking to pursue research and get as far as he did, he advised: \u201cIf you want to be great, work hard and treat others with respect, if you do that, you&#8217;ll not only be successful, you&#8217;ll even be a leader&#8221;.<\/p>\n\n\n\n<p>Also, he recalled the importance of spending time in research laboratories during their formation and finding mentors, to know if research is really what interests them, in addition to teaming up. &#8220;All the things that I accomplished were because I had amazing people in my lab who believed in the science we were doing.&#8221;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Physician and scientist Ronald DePinho explains the relationship of telomere dysfunction to cancer and aging.<\/p>\n","protected":false},"author":12,"featured_media":157546,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[86],"tags":[397,396,224,144],"class_list":["post-157545","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-cancer","tag-giants-of-medicine","tag-health","tag-tecsalud"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v27.6) - 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Creo que la ciencia, al fomentar el pensamiento cr\u00edtico, puede empoderar a la humanidad y, al ser la base de los avances tecnol\u00f3gicos, puede ayudarla a vivir en las mejores condiciones posibles.","url":"https:\/\/tecscience.tec.mx\/en\/author\/igutierrez\/"}]}},"_links":{"self":[{"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/posts\/157545","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/users\/12"}],"replies":[{"embeddable":true,"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/comments?post=157545"}],"version-history":[{"count":0,"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/posts\/157545\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/media\/157546"}],"wp:attachment":[{"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/media?parent=157545"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/categories?post=157545"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/tecscience.tec.mx\/en\/wp-json\/wp\/v2\/tags?post=157545"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}