{"id":160930,"date":"2024-03-15T21:42:34","date_gmt":"2024-03-15T21:42:34","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=160930"},"modified":"2024-12-09T13:28:59","modified_gmt":"2024-12-09T19:28:59","slug":"antimicrobial-resistance","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/","title":{"rendered":"C\u00e9sar De la Fuente: The Researcher Attempting to Revive Extinct Molecules"},"content":{"rendered":"\n<p>Just like something out of Jurassic Park, biotechnologist <a href=\"https:\/\/www.linkedin.com\/in\/cesardelafuentenunez\/\" target=\"_blank\" rel=\"noreferrer noopener\">C\u00e9sar de la Fuente<\/a> from the <a href=\"https:\/\/www.upenn.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Pennsylvania<\/a>, who was listed as one of the top 10 innovators under 35 by the Massachusetts Institute of Technology (MIT), explains his research on the invention <strong>of new antibiotics that help to combat antimicrobial resistance.<\/strong><br><\/p>\n\n\n\n<p>In Steven Spielberg\u2019s 1993 movie, scientists extract DNA from fossilized mosquitoes that had fed on dinosaurs. Using this information, they are able to recreate their genomes and clone the embryos of dinosaurs that will soon inhabit a theme park. That\u2019s what inspired De La Fuente.<br><\/p>\n\n\n\n<p>As they are used to adapt to any environment, bacteria have developed such a resistance to antibiotics that the United Nations (UN) has said <strong>they could be responsible for ten million deaths a year by 2050.<\/strong> <\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-twitter wp-block-embed-twitter\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\">(1\/2)Check out our latest paper with <a href=\"https:\/\/twitter.com\/luispedrocoelho?ref_src=twsrc%5Etfw\">@luispedrocoelho<\/a> and <a href=\"https:\/\/twitter.com\/celiodiasjunior?ref_src=twsrc%5Etfw\">@celiodiasjunior<\/a> in <a href=\"https:\/\/twitter.com\/WileyGlobal?ref_src=twsrc%5Etfw\">@WileyGlobal<\/a> Proteomics. We cover limitations of traditional methods and alternative approaches for discovering novel bioactive peptides. <a href=\"https:\/\/t.co\/XaDyWwwl5r\">https:\/\/t.co\/XaDyWwwl5r<\/a><\/p>&mdash; C\u00e9sar de la Fuente (@delafuenteupenn) <a href=\"https:\/\/twitter.com\/delafuenteupenn\/status\/1767562194911166844?ref_src=twsrc%5Etfw\">March 12, 2024<\/a><\/blockquote><script async src=\"https:\/\/platform.twitter.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-how-can-we-create-better-antibiotics-cesar-de-la-fuente-explains\"><strong>How Can We Create Better Antibiotics? C\u00e9sar De la Fuente Explains<\/strong><\/h2>\n\n\n\n<p>The problem, explains C\u00e9sar De la Fuente, is that bacteria split in minutes, which enables them to acquire mutations and survive in such inhospitable environments as volcanoes or the seabed. \u201cThat\u2019s what makes them fascinating,\u201d says the biotechnologist.<\/p>\n\n\n\n<p>For C\u00e9sar De la Fuente, <strong>antibiotics are the most important invention made by medicine.<\/strong> Before their discovery, people used to die from any infection such as falling over and scraping their knees.<\/p>\n\n\n\n<p>\u201c<strong>Modern medicine would collapse without antibiotics<\/strong>. As interventions such as chemotherapy treatment are immunosuppressed, patients can get infected by any bacteria. When giving birth, mothers can also get infected\u201d explains the expert.<\/p>\n\n\n\n<p>However, <strong>bacteria have done what they know best: adapt.<\/strong> This is due in part to <strong>antibiotics being mass-prescribed to patients in hospitals<\/strong>, as well as the livestock industry using them on animals.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-spotify wp-block-embed-spotify wp-embed-aspect-21-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Spotify Embed: Ep. 81 - Antibi\u00f3ticos del futuro: la esperanza contra las superbacterias\" style=\"border-radius: 12px\" width=\"100%\" height=\"152\" frameborder=\"0\" allowfullscreen allow=\"autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture\" loading=\"lazy\" src=\"https:\/\/open.spotify.com\/embed\/episode\/4853vn7RYXI3ihIDbbkK66?si=e3d379181d744c6e&#038;utm_source=oembed\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-antibiotics-created-with-ai\"><strong>Antibiotics Created with AI<\/strong><\/h2>\n\n\n\n<p><strong>We have to look to nature to find an antibiotic, explains De La Fuente.<\/strong> For instance, by studying fungi to find a molecule that can combat certain bacteria. Hard research can then take up to ten years to turn this into a medicine. However, this process can be reduced to just a few weeks with the aid of <a href=\"http:\/\/en\/tag\/artificial-intelligence\/\" target=\"_blank\" rel=\"noreferrer noopener\">Artificial Intelligence.<\/a><\/p>\n\n\n\n<p>It all began over a decade ago, when he was finishing his doctorate. <strong>The researcher thought that he could use the then incipient AI for studying biology.<\/strong><\/p>\n\n\n\n<p>\u201cThat\u2019s when we decided to get inspired by the greatest tool of diversity: evolution. And we taught a computer to execute this algorithm. We saw that a machine could create an antibiotic,\u201d he says.<br>How did this happen? <\/p>\n\n\n\n<p>The AI provided a sequence of molecules that could then be created in the laboratory with chemical methods. As if following a recipe,<strong> his team followed this sequence and were able to make a molecule that attacked bacteria.<\/strong> Then came the part inspired by Jurassic Park.<\/p>\n\n\n\n<p>\u201cWe decided to explore the proteomes of our cousins, the Neanderthals, to find out if we could discover coded sequences in their proteomes. <strong>That led us to find antibiotics coded into ancient humans<\/strong>,\u201d he says.<\/p>\n\n\n\n<p>Still to come was the most exciting part of their research, when they set themselves the task of reviving those extinct molecules. One of them was Neanderthalin-1, which is one of the antibiotics that were effective on mice models.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The biotechnologist from the University of Pennsylvania is studying new antibiotics to combat resistant bacteria.<\/p>\n","protected":false},"author":24,"featured_media":160932,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[93],"tags":[356,156],"class_list":["post-160930","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotechnology","tag-artificial-intelligence","tag-biotechnology"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>How can we have better antibiotics? C\u00e9sar de la Fuente explains | TecScience<\/title>\n<meta name=\"description\" content=\"Expert studies new antibiotics with the application of AI to help fight antimicrobial resistance\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"C\u00e9sar De la Fuente: The Researcher Attempting to Revive Extinct Molecules\" \/>\n<meta property=\"og:description\" content=\"Expert studies new antibiotics with the application of AI to help fight antimicrobial resistance\" \/>\n<meta property=\"og:url\" content=\"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/\" \/>\n<meta property=\"og:site_name\" content=\"TecScience\" \/>\n<meta property=\"article:published_time\" content=\"2024-03-15T21:42:34+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-09T19:28:59+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/03\/antimicrobial-resistance.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"790\" \/>\n\t<meta property=\"og:image:height\" content=\"611\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Daniel Melchor\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Daniel Melchor\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/biotechnology\\\/antimicrobial-resistance\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/biotechnology\\\/antimicrobial-resistance\\\/\"},\"author\":{\"name\":\"Daniel Melchor\",\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/#\\\/schema\\\/person\\\/8d23afb94097012190a6aeea73edcb07\"},\"headline\":\"C\u00e9sar De la Fuente: The Researcher Attempting to Revive Extinct Molecules\",\"datePublished\":\"2024-03-15T21:42:34+00:00\",\"dateModified\":\"2024-12-09T19:28:59+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/biotechnology\\\/antimicrobial-resistance\\\/\"},\"wordCount\":562,\"publisher\":{\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/biotechnology\\\/antimicrobial-resistance\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/wp-content\\\/uploads\\\/sites\\\/9\\\/2024\\\/03\\\/antimicrobial-resistance.jpg\",\"keywords\":[\"artificial intelligence\",\"biotechnology\"],\"articleSection\":[\"Biotechnology\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/biotechnology\\\/antimicrobial-resistance\\\/\",\"url\":\"https:\\\/\\\/tecscience.tec.mx\\\/en\\\/biotechnology\\\/antimicrobial-resistance\\\/\",\"name\":\"How can we have better antibiotics? 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Individual bacterium are shown as pink rod shapes with multiple hair-like flagella used for motility. The Enterobacteriaceae family contains over a hundred species including Shigella, Klebsiella, Salmonella and Escherichia coli and can be found in animal guts, water and soil. 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C\u00e9sar de la Fuente explains | TecScience","isPartOf":{"@id":"https:\/\/tecscience.tec.mx\/en\/#website"},"primaryImageOfPage":{"@id":"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/#primaryimage"},"image":{"@id":"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/#primaryimage"},"thumbnailUrl":"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/03\/antimicrobial-resistance.jpg","datePublished":"2024-03-15T21:42:34+00:00","dateModified":"2024-12-09T19:28:59+00:00","description":"Expert studies new antibiotics with the application of AI to help fight antimicrobial resistance","breadcrumb":{"@id":"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/tecscience.tec.mx\/en\/biotechnology\/antimicrobial-resistance\/#primaryimage","url":"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/03\/antimicrobial-resistance.jpg","contentUrl":"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/03\/antimicrobial-resistance.jpg","width":790,"height":611,"caption":"Illustration of Enterobacteriaceae bacteria. 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