{"id":161362,"date":"2024-04-01T09:06:04","date_gmt":"2024-04-01T15:06:04","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=161362"},"modified":"2024-12-10T17:16:50","modified_gmt":"2024-12-10T23:16:50","slug":"xenotransplantation","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/health\/xenotransplantation\/","title":{"rendered":"Xenotransplantation: Successful Cases and the Next Steps"},"content":{"rendered":"\n<p>All <strong>organ donations<\/strong> are made voluntarily, but they cover only 10% of the global need, which is why <strong>xenotransplantation<\/strong> has brought new hope.<\/p>\n\n\n\n<p>As gene editing brings us closer to such a possibility, it\u2019s important to know what it is and what bioethical issues it presents.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-what-is-xenotransplantation\">What is Xenotransplantation?<\/h2>\n\n\n\n<p>Xenotransplantation involves transferring cells, <a href=\"\/en\/biotechnology\/chaotic-printing\/\" target=\"_blank\" rel=\"noreferrer noopener\">tissues<\/a>, or organs from animals to humans. For <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3246856\/\" target=\"_blank\" rel=\"noreferrer noopener\">300 years<\/a> this procedure was something that only existed in the imagination. The first documented attempts included blood transfusions and <strong>frog-skin grafts.<\/strong><\/p>\n\n\n\n<p>In the 1960s, French and American scientists attempted, unsuccessfully, to use chimpanzee and baboon hearts and kidneys as replacements for diseased organs in humans.<\/p>\n\n\n\n<p>Over time, the genome sequencing of thousands of species has revived these ideas. DNA sequencing has brought pigs to the fore.<\/p>\n\n\n\n<p>The reproductive maturity of these animals, their gestation period, and the size of their organs <strong>has qualified them as the best candidates for these procedures.<\/strong> Another significant step was the human experience of exploiting them for meat production, something that seems to translate into unlimited access to organs.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-spotify wp-block-embed-spotify wp-embed-aspect-21-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Spotify Embed: Ep. 80 - Vivir con un coraz\u00f3n de cerdo. \u00bfLos xenotrasplantes podr\u00edan resolver el desabasto de \u00f3rganos?\" style=\"border-radius: 12px\" width=\"100%\" height=\"152\" frameborder=\"0\" allowfullscreen allow=\"autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture\" loading=\"lazy\" src=\"https:\/\/open.spotify.com\/embed\/episode\/1HTexZvOUu3OLxqTbQSj9W?si=54c646bc05174a7b&#038;utm_source=oembed\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-pig-heart-transplant\">Pig Heart Transplant<\/h2>\n\n\n\n<p>The biggest boost to xenotransplantation research has been gene-editing technology, particularly <a href=\"\/en\/biotechnology\/chemistry-nobel-prize-awarded-women\/\" target=\"_blank\" rel=\"noreferrer noopener\">CRISPR-Cas9<\/a>, which works like molecular scissors to cut DNA precisely.<\/p>\n\n\n\n<p>Thus far, the viability of modified organs has been tested in brain-dead patients, but it has been unsuccessful in the long term. The furthest it\u2019s been reached are two clinical trials at the <a href=\"https:\/\/umd.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Maryland<\/a>; the patients were David Bennett and Lawrence Faucette,<strong> one of whom survived with a pig heart for two months and the other for six weeks.<\/strong><\/p>\n\n\n\n<p>In Argentina, <a href=\"https:\/\/www.conicet.gov.ar\/new_scp\/detalle.php?keywords=&amp;id=33789&amp;datos_academicos=yes\" target=\"_blank\" rel=\"noreferrer noopener\">Laura Ratner<\/a> from the Animal Biotechnology Laboratory (LabBA) at the University of Buenos Aires, is part of the <strong>first group in Latin America to achieve a litter of genetically modified pigs.<\/strong> Although the genes responsible for hyperacute rejection have been removed from the piglets, other genes that would enhance their compatibility with humans need to be inserted.<\/p>\n\n\n\n<p>Research groups working with xenotransplantation still have a long way to go in order to come up with a safe solution. Pending tasks include overcoming long-term immunological rejection, preventing the transmission of diseases, and developing bioethical protocols that guarantee that a decades-long dream is achieved under optimal conditions.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><picture>\r\n                <source srcset=\"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/04\/kidney-pig-transplant.webp\" type=\"image\/webp\">\r\n                <img fetchpriority=\"high\" decoding=\"async\" width=\"750\" height=\"500\" src=\"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/04\/kidney-pig-transplant.jpg\" alt=\"Massachusetts General Hospital (MGH)  \" class=\"wp-image-161364\" srcset=\"https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/04\/kidney-pig-transplant.jpg 750w, https:\/\/tecscience.tec.mx\/en\/wp-content\/uploads\/sites\/9\/2024\/04\/kidney-pig-transplant-300x200.jpg 300w\" sizes=\"(max-width: 750px) 100vw, 750px\" \/>\r\n            <\/picture><figcaption class=\"wp-element-caption\">Massachusetts General Hospital (MGH) has announced the world\u2019s first successful xenotransplantation of a genetically edited pig kidney into a 62-year-old man. (Photo: Reuters)<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\" id=\"h-man-who-received-pig-kidney-marks-a-milestone\">Man Who Received Pig Kidney Marks a Milestone<\/h2>\n\n\n\n<p>A 62-year-old man with end-stage kidney failure became the <strong>first human to receive a genetically-edited pig kidney<\/strong>, announced doctors from Massachusetts General Hospital in Boston, United States, on March 28.<\/p>\n\n\n\n<p>The transplant operation, which lasted four hours and was performed on March 16, marks a major milestone in the quest to provide more readily available organs to patients, the hospital said in a <a href=\"https:\/\/www.massgeneral.org\/news\/press-release\/worlds-first-genetically-edited-pig-kidney-transplant-into-living-recipient\" target=\"_blank\" rel=\"noreferrer noopener\">statement<\/a>.<\/p>\n\n\n\n<p>The patient, Richard Slayman of Weymouth, Massachusetts, <strong>recovered well and was discharged April 3<\/strong>, the hospital said. Unfortunately, on May 11th his decease was reported by his family although the doctors said that <strong>they had no indication that his &#8220;sudden passing&#8221; was the result of his recent transplant.<\/strong><\/p>\n\n\n\n<p>Slayman had received a transplant of a human kidney at the same hospital in 2018 after seven years on dialysis, but the organ failed after five years and he had resumed dialysis treatments.<\/p>\n\n\n\n<p><strong>The pig kidney was provided by eGenesis, of Cambridge, Massachusetts<\/strong>, from a pig that had been genetically edited to remove genes that could be harmful to a human recipient and add other human genes to improve compatibility. This company also deactivated certain viruses inherent to pigs that are able to infect humans.<\/p>\n\n\n\n<p>Kidneys from similarly edited pigs raised by eGenesis had <strong>successfully been transplanted into monkeys that were kept alive for an average of 176 days<\/strong>, and in one case for more than two years, researchers reported in October in the journal Nature.<\/p>\n\n\n\n<p>Drugs used to help prevent rejection of the organ by the patient\u2019s immune system included an experimental antibody treatment called Tegoprubart, developed by Eledon Pharmaceuticals.<br>The pig kidney procedure brings the field of xenotransplantation closer to a possible solution regarding the global organ shortage.<\/p>\n\n\n\n<p>According to the United Network for Organ Sharing (UNOS), more than 100,000 people in the United States await an organ for transplant and <strong>kidneys are the most common organ needed for transplants<\/strong>. <em>(With information from Reuters)<\/em><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Gene editing has enabled significant progress to be made in the waitlist for organs, which entails new challenges for this field.<\/p>\n","protected":false},"author":29,"featured_media":161365,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[86],"tags":[224],"class_list":["post-161362","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v27.5) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>What is xenotransplantation? 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