{"id":162693,"date":"2024-05-23T17:11:00","date_gmt":"2024-05-23T23:11:00","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=162693"},"modified":"2024-12-10T17:11:26","modified_gmt":"2024-12-10T23:11:26","slug":"keto-diet-accelerates-aging","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/health\/keto-diet-accelerates-aging\/","title":{"rendered":"New Study Reveals That Keto Diet Accelerates Organ Aging"},"content":{"rendered":"\n<p>Research published in the <strong><em>Science Advances<\/em><\/strong> journal reveals that following a <strong>ketogenic<\/strong> or <strong>keto diet<\/strong> over a long period can <strong>accelerate the aging of our organ cells<\/strong>, increasing the risk of heart disease, kidney disease, and cancer.<\/p>\n\n\n\n<p>However, different experiments with mice also found that <strong>this aging can be reversed<\/strong> by switching to a standard diet and can even be prevented by following a <strong>keto diet<\/strong> on an <strong>intermittent<\/strong> basis.<\/p>\n\n\n\n<p><a href=\"https:\/\/www.science.org\/doi\/10.1126\/sciadv.ado1463\" target=\"_blank\" rel=\"noreferrer noopener\"><em>Ketogenic diet induces p53-dependent cellular senescence in multiple organs<\/em><\/a> was a study conducted by more than 20 researchers at the <strong>University of Texas Health Science Center at San Antonio <\/strong>(UT Health San Antonio) led by <strong>David Gius,<\/strong> a professor in the Department of Radiation Oncology at the School of Medicine and Associate Cancer Center Director of Translational Research at the Mays Cancer Center.&nbsp;<\/p>\n\n\n\n<p>First, what is <strong>senescence<\/strong>? Biologically, it refers to<strong> the aging of cells <\/strong>until they stop dividing but do not die, entering a kind of \u201czombie state.\u201d<\/p>\n\n\n\n<p>These cells remain in the tissues, accumulate over time in greater quantities and \u201c<strong>release harmful substances<\/strong> that <strong>may cause inflammation and damage to nearby healthy cells<\/strong>. Senescence may play a role in the development of cancer and other diseases,\u201d states the <a href=\"https:\/\/www.cancer.gov\/espanol\/publicaciones\/diccionarios\/diccionario-cancer\/def\/senescencia\" target=\"_blank\" rel=\"noreferrer noopener\">U.S. National Cancer Institute website<\/a>.<\/p>\n\n\n\n<p>Second, what do the researchers mean by <strong>p53<\/strong>? Known as the \u201c<strong>guardian of the genome<\/strong>\u201d or \u201c<strong>tumor suppressor<\/strong>,\u201d it is a <strong>gene that produces a protein<\/strong> found in the nucleus of cells that is activated when cells suffer DNA damage, by activated oncogenes and in response to certain stress signals.&nbsp;<\/p>\n\n\n\n<p>\u201cIt normally helps prevent the development of cancer, and <strong>mutations in the p53 gene<\/strong> are one of the most common <strong>genetic abnormalities<\/strong> in <strong>human cancers<\/strong>,\u201d states the <a href=\"https:\/\/www.cun.es\/diccionario-medico\/terminos\/p53#:~:text=El%20gen%20p53%20es%20un,comunes%20en%20los%20c%C3%A1nceres%20humanos.\" target=\"_blank\" rel=\"noreferrer noopener\">University of Navarra website<\/a>.<\/p>\n\n\n\n<p>Having clarified these concepts, let\u2019s address the <a href=\"\/en\/health\/what-is-the-keto-diet\/\" target=\"_blank\" rel=\"noreferrer noopener\">ketogenic diet, based on a high-fat (over 70%) and low-carbohydrate intake<\/a>, which has proven effective in the treatment of refractory epilepsy and is being investigated for its positive effects on neurodegenerative diseases, though it has been gaining popularity for some decades due to its effect on weight loss.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"\u00bfLa dieta keto es peligrosa para la salud? Esto dice la ciencia\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/AauMSA1IpNE?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><figcaption class=\"wp-element-caption\">Subtitles available in english.<\/figcaption><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>How Did the Study Reveal That the Keto Diet Accelerates Aging?<\/strong><\/h2>\n\n\n\n<p>According to a story published on the <a href=\"https:\/\/news.uthscsa.edu\/a-long-term-ketogenic-diet-accumulates-aged-cells-in-normal-tissues-a-ut-health-san-antonio-led-study-shows\/\" target=\"_blank\" rel=\"noreferrer noopener\">UT Health San Antonio website<\/a>, research leader <strong>David Gius<\/strong> says that 13 million Americans follow a <strong>keto diet<\/strong>. Together with his team, he aimed to understand the impact this dietary plan has on the <strong>p53 gene<\/strong> and its implications for <strong>cellular senescence<\/strong>.<\/p>\n\n\n\n<p>During the research, <strong>mice<\/strong> of different ages (6, 16, 24, and 52 weeks) were <strong>fed<\/strong> for three weeks on a <strong>ketogenic diet<\/strong>, in which 90% of their calories came from fat and less than 1% from carbohydrates.&nbsp;<\/p>\n\n\n\n<p>Also, a <strong>control group<\/strong> was fed a <strong>standard diet<\/strong> in which 17% of calories came from fat and 58% from carbohydrates.&nbsp;<\/p>\n\n\n\n<p><strong>Tissue samples from their hearts, kidneys, livers, and brains<\/strong> were then analyzed to determine the condition of their cells.&nbsp;<\/p>\n\n\n\n<p>Mice on a <strong>ketogenic diet<\/strong>, regardless of age, had higher levels of the protein released by <strong>p53<\/strong>, which can be activated by stress, and had <strong>more senescent cells<\/strong> in their organs than those on a standard diet.<\/p>\n\n\n\n<p>For example, animals fed a <strong>ketogenic diet<\/strong> had on average four times the amount of a <strong>cellular senescence<\/strong> marker in their kidneys than those on a regular diet.<\/p>\n\n\n\n<p>As <strong>senescent cells<\/strong> increase with age, the results of this research suggest that the<strong> ketogenic diet<\/strong> may <strong>accelerate organ aging<\/strong>, increasing the risk of heart disease, cancer, and type 2 diabetes.&nbsp;<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"La importancia de los l\u00e1cteos en la nutrici\u00f3n infantil\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/0QN7-7ayMMc?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Is Keto-Induced Senescence Reversible?<\/strong><\/h2>\n\n\n\n<p>Yes. According to this research, <strong>keto diet<\/strong>-induced <strong>cellular senescence<\/strong> is <strong>time-dependent and reversible:<\/strong> We subjected mice to this regimen for seven days, then returned them to a normal diet and observed that after one week the levels of p53, p21 and SA-\u03b2-gal (which induce senescence) decreased and continued to drop to the control range after two to three weeks.&nbsp;<\/p>\n\n\n\n<p>The study also revealed that administering a <strong>senolytic <\/strong>(a pharmaceutical) selectively eliminates senescent cells by binding to and inhibiting multiple anti-apoptotic proteins in mice that had been on a <strong>ketogenic diet for 21 days<\/strong>.&nbsp;<\/p>\n\n\n\n<p>The results showed that when the <strong>drug was applied for seven days<\/strong> immediately after the end of the keto diet, most of the <strong>senescent cells<\/strong> were<strong> successfully eliminated<\/strong> but those who were treated one week after the end of the diet still had high levels of senescence.&nbsp;<\/p>\n\n\n\n<p>Finally, the researchers tested whether an <strong>intermittent ketogenic diet<\/strong> would prevent p53 activation and cellular senescence. They fed the mice a keto diet for four days and alternated with a standard diet for three cycles of seven days.&nbsp;<\/p>\n\n\n\n<p>Two other groups were fed a ketogenic diet (positive control) and a standard diet (negative control) for 31 days. Contrary to the sustained <strong>keto diet<\/strong>, the <strong>intermittent diet did not increase p53 or cellular senescence<\/strong>.&nbsp;<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Why Is This Research Important?<\/strong><\/h2>\n\n\n\n<p>Although such dietary plans have proven positive for treating certain diseases, there is <strong>controversy over their long-term effects.<\/strong>&nbsp;<\/p>\n\n\n\n<p>Citing <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/32694683\/\" target=\"_blank\" rel=\"noreferrer noopener\">a 2020 study<\/a>, the University of Texas researchers highlight that <strong>in the short term<\/strong>, the <strong>keto diet<\/strong> can improve metabolism by activating resident, tissue-specific immune cells, although continued over the <strong>long term<\/strong>, it induces systemic inflammation, obesity, and glucose intolerance.&nbsp;<\/p>\n\n\n\n<p>Based on this paper, the researchers aimed to investigate further the detrimental <strong>long-term<\/strong> <strong>effects<\/strong>: \u201cOur experiments have shown that a <strong>ketogenic diet<\/strong> can induce <strong>p53<\/strong> signaling through AMPK activation combined with inactivation of MDM2 by caspase-2 cleavage, ultimately leading to an increase in p21 and <strong>cellular senescence in multiple organs<\/strong>.\u201d<\/p>\n\n\n\n<p>\u201cBecause we observed these changes in key organs such as the <strong>heart<\/strong> and <strong>kidneys<\/strong>, where the accumulation of <strong>senescent cells<\/strong> can contribute to systemic inflammation and toxicity, we believe that <strong>they have important clinical implications<\/strong>.\u201d<\/p>\n\n\n\n<p>Another important finding of this research is that the <strong>keto diet<\/strong> applied <strong>intermittently<\/strong> may be easier for patients to adhere to and <strong>improve health parameters without the risk of cellular senescence<\/strong> that occurs with long-term keto diets.&nbsp;<\/p>\n\n\n\n<p>Gius and his team acknowledge that more studies are needed to add to this research \u201cto determine whether an <strong>intermittent ketogenic diet<\/strong> might be beneficial in humans and for which conditions, as well as the optimal regimen for each patient.\u201d<\/p>\n\n\n\n<p><strong><em>Did you find this story interesting? Would you like to publish it? Get in touch with our content editor at marianaleonm@tec.mx to find out more.<\/em><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>According to researchers at the University of Texas, it can accelerate aging of the heart, liver, and brain and increase the risk of cancer.<\/p>\n","protected":false},"author":41,"featured_media":162696,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[86],"tags":[224,144],"class_list":["post-162693","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-health","tag-tecsalud"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v27.4) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Keto diet accelerates aging of organs, says new study | TecScience<\/title>\n<meta name=\"description\" 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