{"id":163531,"date":"2024-07-08T13:50:30","date_gmt":"2024-07-08T19:50:30","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=163531"},"modified":"2024-12-10T17:06:41","modified_gmt":"2024-12-10T23:06:41","slug":"combined-covid19-vaccine","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/health\/combined-covid19-vaccine\/","title":{"rendered":"Results Are Looking Promising for a Combined COVID-19 Vaccine"},"content":{"rendered":"\n<p>Moderna <a href=\"https:\/\/investors.modernatx.com\/news\/news-details\/2024\/Moderna-Announces-Positive-Phase-3-Data-for-Combination-Vaccine-Against-Influenza-and-COVID-19-\/default.aspx\" target=\"_blank\" rel=\"noreferrer noopener\">announced<\/a> <strong>positive results for its phase 3 clinical trial<\/strong> of a combined vaccine against <a href=\"\/en\/tag\/covid-19\/\" target=\"_blank\" rel=\"noreferrer noopener\">COVID-19<\/a> and influenza. So what exactly did the trial find? And what sort of impact would a <strong>two-in-one COVID-19 and flu vaccine<\/strong> have on public health? <a href=\"https:\/\/theconversation.com\/profiles\/jaya-dantas-316992\" target=\"_blank\" rel=\"noreferrer noopener\">Jaya Dantas<\/a>, International Dean of the Faculty of Health Sciences and Professor of International Health at Curtin University, explains the implications in detail.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Combination Vaccines Are Already Used for Other Diseases<\/h2>\n\n\n\n<p>Combination vaccines have been successfully used for several decades in Australia and around the world.<\/p>\n\n\n\n<p>For example, the DTP vaccine, a shot that combines protection against <strong>diphtheria, tetanus and <em>pertussis<\/em> (whooping cough)<\/strong>, was first administered<a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3068581\/\" target=\"_blank\" rel=\"noreferrer noopener\"> in 1948.<\/a><\/p>\n\n\n\n<p>The DTP vaccine has since been further combined to offer protection against other diseases. A <a href=\"https:\/\/immunisationhandbook.health.gov.au\/vaccines\/infanrix-hexa\" target=\"_blank\" rel=\"noreferrer noopener\">hexavalent vaccine<\/a>, which <strong>protects against six diseases \u2013 diphtheria, tetanus, pertussis, polio, hepatitis B and <em>Haemophilus influenzae<\/em> type b<\/strong> (an infection that can cause brain swelling) \u2013 is today part of routine childhood immunisation programs around the world.<\/p>\n\n\n\n<p>Another important combination vaccine is the MMR vaccine, given to children to protect <strong>against measles, mumps and rubella.<\/strong><\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-spotify wp-block-embed-spotify wp-embed-aspect-21-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Spotify Embed: Ep. 18 - \u00a1Help! No conf\u00edo en las vacunas contra la covid-19\" style=\"border-radius: 12px\" width=\"100%\" height=\"152\" frameborder=\"0\" allowfullscreen allow=\"autoplay; clipboard-write; encrypted-media; fullscreen; picture-in-picture\" loading=\"lazy\" src=\"https:\/\/open.spotify.com\/embed\/episode\/2Po3zynshu1vvdjyxoNlYm?si=c1d74952ab8a4ca2&#038;utm_source=oembed\"><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">So What Did the Trial Find?<\/h2>\n\n\n\n<p>Moderna\u2019s phase 3 trial included roughly <strong>8,000 participants across two age groups<\/strong>. Half were adults aged 50 to 64. The other half were aged 65 and up.<\/p>\n\n\n\n<p>In both age groups, participants were <a href=\"https:\/\/www.mrcctu.ucl.ac.uk\/patients-public\/about-clinical-trials\/what-is-a-randomised-clinical-trial\/\" target=\"_blank\" rel=\"noreferrer noopener\">randomised<\/a> to either receive the combined vaccine (called mRNA-1083) or a control. The control groups received a COVID-19 vaccine and a suitable flu vaccine delivered separately.<\/p>\n\n\n\n<p>The control group in the 50-to-64 age category were given the Fluarix flu vaccine, as well as Moderna\u2019s mRNA COVID-19 vaccine, Spikevax. The over-65 control group received Spikevax alongside Fluzone HD, an enhanced flu vaccine designed specifically for older adults.<\/p>\n\n\n\n<p><strong>The study evaluated safety, including any reactions<\/strong> after vaccination, and the protective immune response the vaccines produced.<\/p>\n\n\n\n<p>Moderna reported the <strong>combined vaccine elicited a higher immune response<\/strong> in both age groups against COVID-19 and three influenza strains, compared to the co-administered shots.<\/p>\n\n\n\n<p>From a safety perspective,<strong> the combined vaccine was well tolerated.<\/strong> Adverse reactions were similar across the experimental and control groups. The most common side effects included muscle aches, fatigue and pain at the injection site.<\/p>\n\n\n\n<p>While the trial results are promising, they are yet to be published in a peer-reviewed journal, which means independent experts haven\u2019t yet verified them. And <strong>further research may be required<\/strong> to test how the combined vaccine works in younger age groups.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">What Are the Advantages of Combined Vaccines?<\/h2>\n\n\n\n<p>We cannot overstate the <a href=\"https:\/\/www.who.int\/news\/item\/30-05-2024-global-partners-celebrate-50-years-of-immunization-progress\" target=\"_blank\" rel=\"noreferrer noopener\">importance of vaccines<\/a>. Each year <strong>they prevent up to <a href=\"https:\/\/www.thelancet.com\/journals\/langlo\/article\/PIIS2214-109X(24)00092-5\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">5 million deaths<\/a> <\/strong>around the world from a range of life-threatening infections.<\/p>\n\n\n\n<p>At the same time, we can always do more to boost vaccination uptake, especially in areas with fewer resources and<strong> among vulnerable populations.<\/strong><\/p>\n\n\n\n<p>Combination vaccines have a <a href=\"https:\/\/www.thelancet.com\/journals\/langlo\/article\/PIIS2214-109X(24)00092-5\/fulltext\" target=\"_blank\" rel=\"noreferrer noopener\">variety of advantages<\/a>. For example, the need for <strong>fewer injections reduces costs for health systems,<\/strong> decreases storage requirements and reduces the burden on parents. All of these things can be especially valuable in low-income countries.<\/p>\n\n\n\n<p>Notably, research shows combination vaccines <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC3068581\/\" target=\"_blank\" rel=\"noreferrer noopener\">make it more likely<\/a> people will take up routine vaccinations.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Two Important Diseases<\/h2>\n\n\n\n<p>Every year, particularly during the winter months, <strong>millions of people contract respiratory infections.<\/strong><\/p>\n\n\n\n<p>According to the World Health Organization (WHO), globally, roughly 3 million to 5 million people experience severe influenza annually, and <strong>around <a href=\"https:\/\/www.who.int\/europe\/news-room\/questions-and-answers\/item\/covid-19--influenza--and-other-respiratory-viruses---2023-2024-autumn-and-winter-season\" target=\"_blank\" rel=\"noreferrer noopener\">650,000 people will die<\/a> from the disease.<\/strong><\/p>\n\n\n\n<p>COVID-19 has resulted in more than <a href=\"https:\/\/www.worldometers.info\/coronavirus\/\" target=\"_blank\" rel=\"noreferrer noopener\">7 million deaths<\/a> around the world to date.<\/p>\n\n\n\n<p>As the COVID-19 pandemic has continued, we\u2019ve seen pandemic fatigue setting in, as some people appear to have become complacent about their COVID shots. A <a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC10222735\/\" target=\"_blank\" rel=\"noreferrer noopener\">2023 study<\/a> in Australia found 30% of the surveyed population were hesitant about and <strong>9% were resistant to taking COVID-19 boosters.<\/strong><\/p>\n\n\n\n<p>Uptake of the flu vaccine, which many people are in the habit of getting annually, may be higher. That said, in Australia the current <a href=\"https:\/\/ncirs.org.au\/influenza-vaccination-coverage-data\" target=\"_blank\" rel=\"noreferrer noopener\">flu vaccine rates<\/a> for 2024 are still fairly low: 53% for adults over 65 years, 26% for those aged 50 to 65, and lower for younger age groups.<\/p>\n\n\n\n<p>A <strong>two-in-one COVID-19 and flu vaccine<\/strong> <strong>could be an <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/36547244\/\" target=\"_blank\" rel=\"noreferrer noopener\">important public health tool<\/a><\/strong> to increase vaccine coverage against these two important diseases. Beyond protecting individuals\u2019 health, this would have flow-on benefits for the economy and our health system.<\/p>\n\n\n\n<p>Moderna said it will present its trial data at an <a href=\"https:\/\/investors.modernatx.com\/news\/news-details\/2024\/Moderna-Announces-Positive-Phase-3-Data-for-Combination-Vaccine-Against-Influenza-and-COVID-19-\/default.aspx\" target=\"_blank\" rel=\"noreferrer noopener\">upcoming medical conference<\/a> and submit it for publication. The company has also said it will soon apply for <a href=\"https:\/\/www.cnbc.com\/2024\/06\/10\/moderna-combination-covid-flu-vaccine-shows-positive-late-stage-data.html\" target=\"_blank\" rel=\"noreferrer noopener\">regulatory approval<\/a>, with <strong>the possibility of supplying the combined vaccine in 2025.<\/strong><\/p>\n\n\n\n<p>At the same time, <a href=\"https:\/\/theconversation.com\/results-are-looking-promising-for-a-combined-covid-and-flu-vaccine-heres-how-it-could-benefit-public-health-232278#:~:text=the%20same%20time%2C-,Pfizer%20and%20BioNTech,-also%20have%20late\" target=\"_blank\" rel=\"noreferrer noopener\">Pfizer and BioNTech<\/a> also have late-stage trials in progress for a combined COVID-19 and flu vaccine. We will await further developments with interest. <a href=\"https:\/\/theconversation.com\/results-are-looking-promising-for-a-combined-covid-and-flu-vaccine-heres-how-it-could-benefit-public-health-232278#:~:text=A%20two%2Din%2Done%20COVID%20and%20flu%20vaccine%20could%20be,economy%20and%20our%20health%20system\" target=\"_blank\" rel=\"noreferrer noopener\">(<em>Via the Conversation.<\/em>)<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Among the anticipated benefits of dual immunization is the reduction of costs among health systems, which would contribute to low-income countries.<\/p>\n","protected":false},"author":18,"featured_media":163537,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[86],"tags":[169,224],"class_list":["post-163531","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-covid-19","tag-health"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v27.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Moderna Presents Combined COVID-19 Vaccine | TecScience<\/title>\n<meta name=\"description\" content=\"Moderna announced positive results for its phase 3 clinical trial of a combined vaccine against COVID-19 and influenza. 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