{"id":165158,"date":"2024-10-03T09:57:43","date_gmt":"2024-10-03T15:57:43","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=165158"},"modified":"2024-12-09T13:22:42","modified_gmt":"2024-12-09T19:22:42","slug":"stem-cells-reverse-diabetes","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/biotechnology\/stem-cells-reverse-diabetes\/","title":{"rendered":"How Stem Cells Reverse Diabetes For The First Time in History"},"content":{"rendered":"\n

For the first time in history, a multidisciplinary team of scientists managed to reverse<\/strong> type 1 diabetes<\/strong> in a 25-year-old patient, who received a reprogrammed stem cell transplant<\/strong> and less than three months later she started producing her own insulin<\/strong>.<\/p>\n\n\n\n

She is the first human<\/strong> with type 1 diabetes<\/a><\/strong> to be treated using cells<\/strong> that were extracted from her own body<\/strong>. The results of his case were published on the specialized site Cell<\/em><\/a> and the success of the procedure is already considered a milestone for modern medicine.\u00a0<\/p>\n\n\n\n

The paper, signed by 35 scientists from various Chinese institutions, explains that the analysis was carried out over a period of one year<\/strong> and corresponds to “a first phase I clinical trial in humans<\/strong> that evaluates the viability of autologous transplantation<\/strong> of islets derived from chemically induced pluripotent stem cells <\/strong>(CiPSC islets) under the anterior rectum abdominal sheath for the treatment of type diabetes 1<\/strong>.”<\/p>\n\n\n\n

What Does It Mean that Stem Cells Can Reverse Diabetes?<\/strong><\/h2>\n\n\n\n

This stem cell transplant <\/strong>that has successfully reversed type 1 diabetes<\/strong> in a Chinese patient represents a major step forward in the treatment of this disease<\/a>, which along with type 2 diabetes<\/a><\/strong>, is considered a chronic condition<\/strong> affecting more than 500 million people worldwide.\u00a0<\/p>\n\n\n\n

According to the World Health Organization (WHO), diabetes<\/strong> “is a chronic metabolic disease<\/strong> characterized by elevated blood glucose<\/strong> (or blood sugar) levels, which over time leads to serious damage<\/strong> to the heart, blood vessels, eyes, kidneys and nerves.”<\/p>\n\n\n\n

“The most common is type 2 diabetes<\/strong>, which occurs when the body becomes insulin resistant or does not produce enough insulin, while type 1 diabetes<\/strong> \u2212once known as juvenile diabetes or insulin\u2212 dependent diabetes is a chronic condition in which the pancreas <\/strong>produces little or no insulin on its own,” adds WHO<\/a>.<\/p>\n\n\n\n

In both cases, patients require a special diet that restricts their sugar intake<\/strong> and they depend on insulin<\/strong> treatments for survival. They also need constant medical check-ups<\/strong>, which entails a huge expense<\/strong> for both individuals and their families, as well as for public health systems. Therefore, finding a cure for diabetes<\/a><\/strong> can transform the lives of millions of people.<\/p>\n\n\n\n

For the specific case of the Chinese patient<\/strong>, the paper details: “she achieved sustained insulin independence <\/strong>starting 75 days post-transplantation<\/strong>. The patient\u2019s time-in-target glycemic range increased from a baseline value of 43.18% to 96.21% by month 4 post-transplantation<\/strong>, accompanied by a decrease in glycated hemoglobin, an indicator of long-term systemic glucose levels at a non-diabetic level<\/strong>.\u201d<\/p>\n\n\n\n

The study adds that \u201cthereafter, the patient presented a state of stable glycemic control<\/strong>, with time-in-target glycemic range at >98% and glycated hemoglobin at around 5%. At 1 year<\/strong>, the clinical data met all study endpoints with no indication of transplant-related abnormalities<\/strong>.\u201d<\/p>\n\n\n\n

Although the woman has chosen to remain anonymous, it is known that she lives in Tianjin, China, is 25 years old and recently gave a telephone interview to Nature<\/a><\/em> magazine in which she said: “I can eat sugar now\u2026 I enjoy eating everything<\/strong>, especially hotpot.\u201d<\/p>\n\n\n\n

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