{"id":173061,"date":"2026-04-13T15:17:35","date_gmt":"2026-04-13T21:17:35","guid":{"rendered":"https:\/\/tecscience.tec.mx\/en\/?p=173061"},"modified":"2026-04-20T09:48:35","modified_gmt":"2026-04-20T15:48:35","slug":"origen-health-research-center","status":"publish","type":"post","link":"https:\/\/tecscience.tec.mx\/en\/health\/origen-health-research-center\/","title":{"rendered":"The Project Aiming to Decode Latin American Health: Obesity, Diabetes, and Aging"},"content":{"rendered":"\n<p>Chronic diseases\u2014such as <a href=\"\/en\/tag\/obesity\/\" target=\"_blank\" rel=\"noreferrer noopener\">obesity<\/a>, <a href=\"\/en\/tag\/diabetes\/\" target=\"_blank\" rel=\"noreferrer noopener\">diabetes<\/a>, and <a href=\"\/en\/tag\/cancer\/\" target=\"_blank\" rel=\"noreferrer noopener\">cancer<\/a>\u2014 <a href=\"https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/noncommunicable-diseases\" target=\"_blank\" rel=\"noreferrer noopener\">are responsible for approximately 75% of deaths worldwide<\/a>. In Latino populations, the risk of developing these diseases is even higher, making it essential to better understand the biological, social, and environmental factors that influence their development. It was in this context that the <a href=\"\/en\/tag\/origen-health-research-center\/\" target=\"_blank\" rel=\"noreferrer noopener\">OriGen Health Research Center<\/a> (OHRC) was established a year ago, a joint initiative between Tecnol\u00f3gico de Monterrey and the <a href=\"https:\/\/www.utexas.edu\/\" target=\"_blank\" rel=\"noreferrer noopener\">University of Texas at Austin<\/a> (UT Austin).<\/p>\n\n\n\n<p>The OHRC is committed to translational research that bridges the gap between scientific knowledge and its application in public health. By integrating disciplines such as genetics, <a href=\"\/en\/tag\/artificial-intelligence\/\" target=\"_blank\" rel=\"noreferrer noopener\">artificial intelligence<\/a>, biomarkers, obesity, and human development, the center aims to build a more comprehensive understanding of these diseases.<\/p>\n\n\n\n<p>Its goal is to generate customized solutions that allow for better prevention, diagnosis, and treatment of illnesses affecting millions of people in the Americas.<\/p>\n\n\n\n<p>To date, the center has launched <strong>three major projects<\/strong> to advance knowledge of these diseases on the continent. These are still in the development phase, but  are expected to yield results throughout this and next year.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-9-16 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"Primer aniversario del OriGen Health Research Center\" width=\"563\" height=\"1000\" src=\"https:\/\/www.youtube.com\/embed\/l-YZbwnZUcY?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Genes, Fat and Health: Understanding Visceral Adiposity in Mexicans<\/h2>\n\n\n\n<p><strong>The first project has as its central question why some people accumulate fat in the abdomen while others, for example, do so in the legs and arms.<\/strong><\/p>\n\n\n\n<p>Where fat is stored is crucial for health and, in many cases, more important than a person&#8217;s total weight or Body Mass Index (BMI). Furthermore, not all fat behaves the same way: subcutaneous fat\u2014which is under the skin\u2014acts as an energy reserve, while <a href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC3473928\/\" target=\"_blank\" rel=\"noreferrer noopener\">visceral fat<\/a> \u2014which accumulates around the organs\u2014has been associated with negative effects on metabolic health.<\/p>\n\n\n\n<p>\u201cAn open question was: what genes influence why someone stores fat in one part of the body versus another?,&#8221; says <a href=\"https:\/\/integrativebio.utexas.edu\/directory\/vagheesh-m-narasimhan\" target=\"_blank\" rel=\"noreferrer noopener\">Vagheesh Narasimhan<\/a>, a researcher at UT Austin and one of the project leaders.<\/p>\n\n\n\n<p>To understand which genes are associated with fat storage, the team will use an advanced artificial intelligence model capable of analyzing large-scale body composition, genetic, and clinical records data to accurately estimate body fat distribution.<\/p>\n\n\n\n<p>The algorithm was originally trained using data from the <a href=\"\/en\/health\/mexican-genome\/\" target=\"_blank\" rel=\"noreferrer noopener\">UK Biobank<\/a> and will be adapted to the Latin American population using genetic, clinical and body composition data collected by the <a href=\"\/en\/tag\/origen-project\/\" target=\"_blank\" rel=\"noreferrer noopener\">oriGen project<\/a>.<\/p>\n\n\n\n<p>This will enable the generation of accessible tools to assess risks in communities associated with the accumulation of visceral fat and to identify key genes that, in the future, could become therapeutic targets for developing drugs like Ozempic, specifically targeting visceral fat.<\/p>\n\n\n\n<p>\u201cUnderstanding the genetic basis of body fat storage might allow us to target those genes and focus not just on overall BMI but \u2014perhaps excitingly\u2014 on body fat that is bad for you,<em>\u201d<\/em> says Narasimhan.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-video is-provider-youtube wp-block-embed-youtube wp-embed-aspect-16-9 wp-has-aspect-ratio\"><div class=\"wp-block-embed__wrapper\">\n<iframe title=\"OriGen: the search for the Mexican genome\" width=\"800\" height=\"450\" src=\"https:\/\/www.youtube.com\/embed\/vFY-gtHQlpo?feature=oembed\" frameborder=\"0\" allow=\"accelerometer; autoplay; clipboard-write; encrypted-media; gyroscope; picture-in-picture; web-share\" referrerpolicy=\"strict-origin-when-cross-origin\" allowfullscreen><\/iframe>\n<\/div><\/figure>\n\n\n\n<h2 class=\"wp-block-heading\">Small Changes, Big Impacts: a New Strategy Against Adolescent Obesity<\/h2>\n\n\n\n<p><strong>Another project focuses on adolescent obesity<\/strong>, a growing challenge that is especially complex in Latino communities where biological, social, and cultural factors intertwine.<\/p>\n\n\n\n<p>Beyond diet, family dynamics, social stigma, and limited access to appropriate treatment all play a role. In response to this situation, the OHRC&#8217;s <em><strong>\u201cSmall Changes in Adolescence Towards a Healthier Weight<\/strong><\/em><strong><em><em>\u201d<\/em><\/em><\/strong> project proposes a new approach to intervention.<\/p>\n\n\n\n<p>The project is based on the premise that obesity is not a matter of willpower, but a complex biological condition that requires <a href=\"\/en\/health\/losing-weight\/\" target=\"_blank\" rel=\"noreferrer noopener\">personalized treatments<\/a>.<\/p>\n\n\n\n<p>The team will develop a digital platform that allows teenagers to design meal plans adapted to their daily lives and what they like to eat, without needing to count calories or follow rigid diets.<\/p>\n\n\n\n<p>\u201cLet&#8217;s say they choose enchiladas as one of their dinner options, the program will tell them exactly the recipe they need to follow to create a meal that fits their plan,<em><em>\u201d<\/em><\/em> explains <a href=\"https:\/\/nutrition.utexas.edu\/directory\/leah-d-whigham\" target=\"_blank\" rel=\"noreferrer noopener\">Leah Whigham<\/a>, a researcher at UT Austin and one of the project leaders.<\/p>\n\n\n\n<p>Thus, the platform will use data such as biological sex, age, height, and nationality to calculate how many calories each teenager burns and design a meal plan that puts them in a calorie deficit and helps them reach a healthy weight.<\/p>\n\n\n\n<p>The program will go beyond nutrition and integrate modules on mental health and family communication, recognizing that support at home is essential to achieving sustainable changes.<\/p>\n\n\n\n<p>\u201cIt can help them address what&#8217;s happening in their body in a positive, healthy way and also understand how to be prepared to face others outside the family who may be stigmatizing,<em>\u201d<\/em> says Whingham.<\/p>\n\n\n\n<p>Because it is scalable and low-cost, this intervention has the potential to reach thousands of young people, transforming the prevention and treatment of obesity in Latin America.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">From Stress to Health: Understanding the Relationship Between Life History and Metabolism<\/h2>\n\n\n\n<p><strong>The third project seeks to understand how <a href=\"\/en?s=stress\" target=\"_blank\" rel=\"noreferrer noopener\">stress<\/a> influences metabolic health throughout the lives of people in Mexico.<\/strong><\/p>\n\n\n\n<p>Aging and metabolic diseases do not occur in isolation, but are the result of decades of accumulated experiences. To understand this relationship, they have proposed the project <strong><em>\u201cDevelopment of a life history survey to study aging and health in Mexico.\u201d<\/em><\/strong><\/p>\n\n\n\n<p>\u201cIn the 80s and 90s, there were a lot of dynamic changes in the Mexican society in terms of economic growth, but also some challenges, so we are thinking about how that&#8217;s altered their ability to have social mobility and access to medical care,<em>\u201d<\/em> says <a href=\"https:\/\/liberalarts.utexas.edu\/prc\/faculty\/mpf434\" target=\"_blank\" rel=\"noreferrer noopener\">Mateo Farina<\/a>, a researcher at UT Austin and one of the project leaders.<\/p>\n\n\n\n<p>Through detailed interviews and the collection of biomarkers, the team will analyze how experiences such as inequality, social mobility, or economic changes influence metabolic processes and aging.<\/p>\n\n\n\n<p>Thus, the approach integrates demography, public health, and biology to map health trajectories over time.<\/p>\n\n\n\n<p>\u201cFor now, we\u2019re limiting it to 200 people in Mexico City, but the long-term goal would be to write a larger grant and get a couple thousand people across all Mexican states,\u201d Farina says.<\/p>\n\n\n\n<p>In a country where diabetes and obesity have grown rapidly, this perspective could allow for the identification of key moments for intervention.<\/p>\n\n\n\n<p>In the long term, the project could transform the way public policies and prevention strategies are designed, incorporating not only clinical factors but also the social conditions that shape the health of populations.<\/p>\n\n\n\n<p><strong><em>Did you find this story interesting? Would you like to publish it? Contact our content editor for more information: <a href=\"mailto:marianaleonm@tec.mx\" target=\"_blank\" rel=\"noreferrer noopener\">marianaleonm@tec.mx<\/a><\/em><\/strong><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>The OriGen Health Research Center is an initiative of Tecnol\u00f3gico de Monterrey and the University of Texas at Austin that seeks to understand the health of Latino populations.<\/p>\n","protected":false},"author":12,"featured_media":173063,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_eb_attr":"","footnotes":""},"categories":[86],"tags":[555,143],"class_list":["post-173061","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-health","tag-origen-health-research-center","tag-origen-project"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v21.0 (Yoast SEO v27.4) - 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